Current Status of HER2 Testing

Current status of HER2 testing: caught between a rock and a hard place.

The analysis of breast cancer specimens for alterations in the HER2/neu (c-erb-B2) gene or its protein product has become common practice in surgical pathology laboratories. Although some clinicians use the information derived from these assays for assessing patient prognosis and evaluating the likelihood of response to various chemotherapeutic agents and to tamoxifen, the major clinical role o...

Current Status of Human Immunodeficiency Virus Testing

Human Immunodeficiency Virus (HIV, HIV-1) is now known to be the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS).1 2 3 As of March, 1988 there are more than 54,000 cases of AIDS, according to reports of the Centers for Disease Control (CDC).4 It is estimated that the total number of infected persons at the present time is 1 to 1.5 million in the United States.~ It is further predic...

Testing Independence for Bivariate Current Status Data

This paper develops a nonparametric procedure for testing marginal independence based on bivariate current status data. Asymptotic properties of the proposed tests are derived and their finite sample performance is studied via simulations. The method is applied to analyze data from a community-based study of cardiovascular epidemiology in Taiwan.

The Current Status of Nondestructive Testing with Positron Annihilation

Current Status of Laboratory Testing for HIV in the Philippines

Prevalence of HIV infection in the Philippines remains low. This may be partly due to reliance on passive reporting for surveillance. The algorithm for laboratory testing for HIV infection has become more stringent in the sense that the screening assays are repeated in the confirmatory centers, before Western Blot is performed. This has been due to the high rate of false positives before 2005. ...